Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.
Identifieur interne : 000548 ( Main/Exploration ); précédent : 000547; suivant : 000549Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.
Auteurs : Young-Il Kim [Corée du Sud] ; Seong-Gyu Kim [Corée du Sud] ; Se-Mi Kim [Corée du Sud] ; Eun-Ha Kim [Corée du Sud] ; Su-Jin Park [Corée du Sud] ; Kwang-Min Yu [Corée du Sud] ; Jae-Hyung Chang [Corée du Sud] ; Eun Ji Kim [Corée du Sud] ; Seunghun Lee [Corée du Sud] ; Mark Anthony B. Casel [Corée du Sud] ; Jihye Um [Corée du Sud] ; Min-Suk Song [Corée du Sud] ; Hye Won Jeong [Corée du Sud] ; Van Dam Lai [Corée du Sud] ; Yeonjae Kim [Corée du Sud] ; Bum Sik Chin [Corée du Sud] ; Jun-Sun Park [Corée du Sud] ; Ki-Hyun Chung [Corée du Sud] ; Suan-Sin Foo [États-Unis] ; Haryoung Poo [Corée du Sud] ; In-Pil Mo [Corée du Sud] ; Ok-Jun Lee [Corée du Sud] ; Richard J. Webby [États-Unis] ; Jae U. Jung [États-Unis] ; Young Ki Choi [Corée du Sud]Source :
- Cell host & microbe [ 1934-6069 ] ; 2020.
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.
DOI: 10.1016/j.chom.2020.03.023
PubMed: 32259477
Affiliations:
- Corée du Sud, États-Unis
- Californie, Région capitale de Séoul, Tennessee
- Los Angeles, Séoul
- Université de Californie du Sud
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Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Park, Su Jin" sort="Park, Su Jin" uniqKey="Park S" first="Su-Jin" last="Park">Su-Jin Park</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Kwang Min" sort="Yu, Kwang Min" uniqKey="Yu K" first="Kwang-Min" last="Yu">Kwang-Min Yu</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Jae Hyung" sort="Chang, Jae Hyung" uniqKey="Chang J" first="Jae-Hyung" last="Chang">Jae-Hyung Chang</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Eun Ji" sort="Kim, Eun Ji" uniqKey="Kim E" first="Eun Ji" last="Kim">Eun Ji Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Seunghun" sort="Lee, Seunghun" uniqKey="Lee S" first="Seunghun" last="Lee">Seunghun Lee</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Casel, Mark Anthony B" sort="Casel, Mark Anthony B" uniqKey="Casel M" first="Mark Anthony B" last="Casel">Mark Anthony B. Casel</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Um, Jihye" sort="Um, Jihye" uniqKey="Um J" first="Jihye" last="Um">Jihye Um</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Jeong, Hye Won" sort="Jeong, Hye Won" uniqKey="Jeong H" first="Hye Won" last="Jeong">Hye Won Jeong</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lai, Van Dam" sort="Lai, Van Dam" uniqKey="Lai V" first="Van Dam" last="Lai">Van Dam Lai</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chung, Ki Hyun" sort="Chung, Ki Hyun" uniqKey="Chung K" first="Ki-Hyun" last="Chung">Ki-Hyun Chung</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Foo, Suan Sin" sort="Foo, Suan Sin" uniqKey="Foo S" first="Suan-Sin" last="Foo">Suan-Sin Foo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Poo, Haryoung" sort="Poo, Haryoung" uniqKey="Poo H" first="Haryoung" last="Poo">Haryoung Poo</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Mo, In Pil" sort="Mo, In Pil" uniqKey="Mo I" first="In-Pil" last="Mo">In-Pil Mo</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ok Jun" sort="Lee, Ok Jun" uniqKey="Lee O" first="Ok-Jun" last="Lee">Ok-Jun Lee</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name><affiliation wicri:level="2"><nlm:affiliation>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Jung, Jae U" sort="Jung, Jae U" uniqKey="Jung J" first="Jae U" last="Jung">Jae U. Jung</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: jaeujung@med.usc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea. Electronic address: choiki55@chungbuk.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32259477</idno><idno type="pmid">32259477</idno><idno type="doi">10.1016/j.chom.2020.03.023</idno><idno type="wicri:Area/PubMed/Corpus">000313</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000313</idno><idno type="wicri:Area/PubMed/Curation">000313</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000313</idno><idno type="wicri:Area/PubMed/Checkpoint">000436</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000436</idno><idno type="wicri:Area/Ncbi/Merge">003790</idno><idno type="wicri:Area/Ncbi/Curation">003790</idno><idno type="wicri:Area/Ncbi/Checkpoint">003790</idno><idno type="wicri:Area/Main/Merge">000548</idno><idno type="wicri:Area/Main/Curation">000548</idno><idno type="wicri:Area/Main/Exploration">000548</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.</title><author><name sortKey="Kim, Young Il" sort="Kim, Young Il" uniqKey="Kim Y" first="Young-Il" last="Kim">Young-Il Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seong Gyu" sort="Kim, Seong Gyu" uniqKey="Kim S" first="Seong-Gyu" last="Kim">Seong-Gyu Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Se Mi" sort="Kim, Se Mi" uniqKey="Kim S" first="Se-Mi" last="Kim">Se-Mi Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Eun Ha" sort="Kim, Eun Ha" uniqKey="Kim E" first="Eun-Ha" last="Kim">Eun-Ha Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Park, Su Jin" sort="Park, Su Jin" uniqKey="Park S" first="Su-Jin" last="Park">Su-Jin Park</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Kwang Min" sort="Yu, Kwang Min" uniqKey="Yu K" first="Kwang-Min" last="Yu">Kwang-Min Yu</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Jae Hyung" sort="Chang, Jae Hyung" uniqKey="Chang J" first="Jae-Hyung" last="Chang">Jae-Hyung Chang</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Eun Ji" sort="Kim, Eun Ji" uniqKey="Kim E" first="Eun Ji" last="Kim">Eun Ji Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Seunghun" sort="Lee, Seunghun" uniqKey="Lee S" first="Seunghun" last="Lee">Seunghun Lee</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Casel, Mark Anthony B" sort="Casel, Mark Anthony B" uniqKey="Casel M" first="Mark Anthony B" last="Casel">Mark Anthony B. Casel</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Um, Jihye" sort="Um, Jihye" uniqKey="Um J" first="Jihye" last="Um">Jihye Um</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Jeong, Hye Won" sort="Jeong, Hye Won" uniqKey="Jeong H" first="Hye Won" last="Jeong">Hye Won Jeong</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lai, Van Dam" sort="Lai, Van Dam" uniqKey="Lai V" first="Van Dam" last="Lai">Van Dam Lai</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chung, Ki Hyun" sort="Chung, Ki Hyun" uniqKey="Chung K" first="Ki-Hyun" last="Chung">Ki-Hyun Chung</name><affiliation wicri:level="3"><nlm:affiliation>Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research institute of Public Health, National Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Foo, Suan Sin" sort="Foo, Suan Sin" uniqKey="Foo S" first="Suan-Sin" last="Foo">Suan-Sin Foo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Poo, Haryoung" sort="Poo, Haryoung" uniqKey="Poo H" first="Haryoung" last="Poo">Haryoung Poo</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Mo, In Pil" sort="Mo, In Pil" uniqKey="Mo I" first="In-Pil" last="Mo">In-Pil Mo</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ok Jun" sort="Lee, Ok Jun" uniqKey="Lee O" first="Ok-Jun" last="Lee">Ok-Jun Lee</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name><affiliation wicri:level="2"><nlm:affiliation>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Jung, Jae U" sort="Jung, Jae U" uniqKey="Jung J" first="Jae U" last="Jung">Jae U. Jung</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: jaeujung@med.usc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea. Electronic address: choiki55@chungbuk.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cell host & microbe</title><idno type="eISSN">1934-6069</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Californie</li><li>Région capitale de Séoul</li><li>Tennessee</li></region><settlement><li>Los Angeles</li><li>Séoul</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Young Il" sort="Kim, Young Il" uniqKey="Kim Y" first="Young-Il" last="Kim">Young-Il Kim</name></noRegion><name sortKey="Casel, Mark Anthony B" sort="Casel, Mark Anthony B" uniqKey="Casel M" first="Mark Anthony B" last="Casel">Mark Anthony B. Casel</name><name sortKey="Chang, Jae Hyung" sort="Chang, Jae Hyung" uniqKey="Chang J" first="Jae-Hyung" last="Chang">Jae-Hyung Chang</name><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name><name sortKey="Chung, Ki Hyun" sort="Chung, Ki Hyun" uniqKey="Chung K" first="Ki-Hyun" last="Chung">Ki-Hyun Chung</name><name sortKey="Jeong, Hye Won" sort="Jeong, Hye Won" uniqKey="Jeong H" first="Hye Won" last="Jeong">Hye Won Jeong</name><name sortKey="Kim, Eun Ha" sort="Kim, Eun Ha" uniqKey="Kim E" first="Eun-Ha" last="Kim">Eun-Ha Kim</name><name sortKey="Kim, Eun Ji" sort="Kim, Eun Ji" uniqKey="Kim E" first="Eun Ji" last="Kim">Eun Ji Kim</name><name sortKey="Kim, Se Mi" sort="Kim, Se Mi" uniqKey="Kim S" first="Se-Mi" last="Kim">Se-Mi Kim</name><name sortKey="Kim, Seong Gyu" sort="Kim, Seong Gyu" uniqKey="Kim S" first="Seong-Gyu" last="Kim">Seong-Gyu Kim</name><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><name sortKey="Lai, Van Dam" sort="Lai, Van Dam" uniqKey="Lai V" first="Van Dam" last="Lai">Van Dam Lai</name><name sortKey="Lee, Ok Jun" sort="Lee, Ok Jun" uniqKey="Lee O" first="Ok-Jun" last="Lee">Ok-Jun Lee</name><name sortKey="Lee, Seunghun" sort="Lee, Seunghun" uniqKey="Lee S" first="Seunghun" last="Lee">Seunghun Lee</name><name sortKey="Mo, In Pil" sort="Mo, In Pil" uniqKey="Mo I" first="In-Pil" last="Mo">In-Pil Mo</name><name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name><name sortKey="Park, Su Jin" sort="Park, Su Jin" uniqKey="Park S" first="Su-Jin" last="Park">Su-Jin Park</name><name sortKey="Poo, Haryoung" sort="Poo, Haryoung" uniqKey="Poo H" first="Haryoung" last="Poo">Haryoung Poo</name><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name><name sortKey="Um, Jihye" sort="Um, Jihye" uniqKey="Um J" first="Jihye" last="Um">Jihye Um</name><name sortKey="Yu, Kwang Min" sort="Yu, Kwang Min" uniqKey="Yu K" first="Kwang-Min" last="Yu">Kwang-Min Yu</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Foo, Suan Sin" sort="Foo, Suan Sin" uniqKey="Foo S" first="Suan-Sin" last="Foo">Suan-Sin Foo</name></region><name sortKey="Jung, Jae U" sort="Jung, Jae U" uniqKey="Jung J" first="Jae U" last="Jung">Jae U. Jung</name><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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